There are quite a few updates to the 2021 Aprilia RSV4 and RSV4 Factory. None of them are revolutionary. However, taken together, they add up to quite a few changes to the legendary superbike.

1. There are still differences between the RSV4 and the RSV4 Factory. The Factory gets forged aluminum wheels, semi-active Öhlins Smart EC 2.0 suspension, and Brembo Stylema brake calipers.
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https://ultimatemotorcycling.com/2021/01/15/2021-aprilia-rsv4-and-rsv4-factory-first-look-11-fast-facts/