If your work involves different varieties of fonts, you might be in for some trouble with macOS Catalina. Here are some techniques you can try to fix the situation.

If you’re a Mac user whose work involves different varieties of fonts, you might be in for some trouble with macOS Catalina. Some people are reporting that after upgrading to the latest version of macOS, excruciating font conflicts occur, the kind that render text unreadable in Mail, Safari, and other places. And if you’ve ever moved font files into the Fonts folders in your Library and User Library folders, or you use a third-party font manager such as FontExplorer X Pro, FontAgent, or Suitcase Fusion you may be in for a rude surprise.
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https://www.macworld.com/article/3528553/font-chaos-in-macos-catalina-and-how-to-deal-with-it.html